卫伟（博导）

发布者：陈飞虹发布时间：2021-07-10浏览次数：2835

卫伟，女，太阳成城集团tyc234cc古天乐教授，博士生导师。1975年2月生，1998年和2001年，分别于河南师范大学获得本科和硕士学位，2004年获得南京大学博士学位。同年到太阳成城集团tyc234cc古天乐工作，先后任职于公共卫生公司和太阳成城集团tyc234cc古天乐。主要涉及的研究领域如下：1.与疾病相关的生物医学检测（蛋白质、酶、DNA等相关标志物检测）；2.肿瘤和神经退行性疾病的诊断和治疗研究；3.环境、食品中农药残留、重金属等有害物质的灵敏检测方法研究；4.食品、烟草、化妆品中香精香料的检测分析；5.食品、烟草中的风味物质（咸、甜、苦、涩、酸）检测传感研究；6.新型纳米材料的合成及其在分析化学（光谱及电化学）研究中的应用。发表SCI论文90余篇，获授权专利20余项。主持并完成国家自然科学基金4项，江苏省自然基金面上项目1项，国家重点研发项目子课题1项。


博士招生方向“化学”、“化学工程”

硕士招生方向“化学工程与技术”、“化学工程”。

       

员工培养：

2023年，陈钰慧获得国家奖学金。

2022年，唐艳华获得国家奖学金。

2019年，王晨晨获得国家奖学金。

2018年，刘叙获得太阳成城集团tyc234cc古天乐优秀硕士论文。

2018年，吴霜霜获得国家奖学金。

2017年，徐晓林获得国家奖学金。

2016年，刘元建、刘叙、吕冰婧获得国家奖学金。

2014年，高春燕获得国家奖学金。


获奖：

2016年，教育部自然科学奖，一等奖， 纳米材料毒理学评价及环境医学应用的基础研究。

2019年，江苏省预防医学科技奖，二等奖，苯造血毒性的机制与生物标志物研究。

科研项目：

  1. 同时检测阿尔茨海默症关键酶活性的方法研究，22274020，国家自然科学基金面上项目。

  2. 聚ADP核糖聚合酶的高通量检测及其生物医学应用研究, 21775019,国家自然科学基金面上项目。

  3. DNA功能化组装及其在肺癌检测和治疗中的应用研究，21475020,国家自然科学基金。

  4. 基于纳米探针的DNA损伤检测新方法及其在化学品基因毒性评价中的应用, 21205014国家自然科学基金青年基金。

  5. 食品安全化学性污染物智能化现场快速检测技术及相关产品研发,科技部重点研发项目，2018YFC1602800，2018年07月- 2021年12月。

  6. 香气释放原位检测。烟草行业烟草香料基础研究重点实验室创新平台开放合作项目。2022.3-2024.12.

  7. 烟碱的电化学检测。2022-2023。郑州烟草研究院。

  8. 涩感物质传感平台构建。北京生命科技研究院，2024-2025

  9. 绿原酸多功能纳米载体MC-H/R/si制备、表征、功效技术服务，2025-2026

  10. 甜度检测生物传感器及甜度生物学指标量化表征方法研究。2023-2025

  11. 粮食中有机磷和氨基甲酸酯类农药残留荧光快速检测技术开发。2021-2022.

  12. 单胺氧化酶活性的检测。2021.7-2.22.7。

  13. 基于DNA损伤检测的化学品基因毒性评价与筛查新方法, BK2012734，江苏省自然科学基金。

专利：

  1. 卫伟，高春燕，刘松琴。 限制性内切酶和核酸外切酶III的无标记荧光检测DNA和DNA甲基化转移酶活性的检测方法。ZL 201410220070.8.授权公告日，2015年11月24日

  2. 卫伟，康学军，邓慧华，陆祖宏。蜂王浆中乙酰胆碱的检测方法。ZL 200910028454.9授权公告日，2012年04月25日

  3. 卫伟，熊艳翔，刘松琴。基于氧化石墨烯和限制性内切酶的DNA甲基化检测方法及其试剂盒。ZL 201310472714.8 授权公告日，2015年1月28日

  4. 卫伟，倪蔷薇，刘松琴。一种电化学DNA生物传感器及其制备方法与应用。ZL 201410035109.9  授权公告日，2016年2月10日

  5. 卫敏，刘叙，卫伟。基于孔道内和电化学传感定量检测端粒酶活性的方法。ZL 20160319908.8授权公告日，2018.06.12

  6. 卫伟，刘元建，刘松琴。一种金纳米粒子探针比色法检测甲型流感病毒H3N2的方法。ZL 201510152842.3。授权公告日，2016年10月19日

  7. 卫伟，范佳慧，张雪红，徐晓林，陈昌慧，刘松琴。基于苯胺沉积的电化学传感定量检测8-OHdG的方法。授理号：201610824784.9.授权日: 2018.10.16

  8. 卫敏，刘叙，卫伟。基于纳米传感和电化学传感定量检测端粒酶活性的方法。授权：201610319908.8.  

  9. 卫伟，刘叙，刘松琴。利用亚甲基蓝与G-四链体的结合检测端粒酶活性检测方法。授权号：201610824783.4.

  10. 卫伟，陈昌慧，刘松琴。基于阳离子水溶性聚合物的荧光可视化定量检测端粒酶活性的检测方法。授权：201610824309.1.

  11. 卫伟，刘元建，刘松琴。一种通过荧光法同时检测多种miRNA的方法。授权ZL201710011874.0

  12. 卫伟，吴霜霜，刘松琴。一种基于金纳米棒比色法检测多聚腺苷二磷酸核糖聚合酶-1的新方法。授理号：201710669001.9，授权20200602

  13. 刘勇，范佳慧，卫伟。基于聚苯胺沉积的定量检测多聚腺苷二磷酸核糖聚合酶-1活性的方法，201710729580.1

  14. 刘勇，徐晓林，卫伟。基于hemin 石墨烯复合材料分析检测PARP活性的方法，授权, 2020.04.03. Zl 201710638454.5

  15. 刘勇，许超，卫伟。一种PARP-1浓度的检测方法及其应用。ZL202010431252.5.授权日：2021.02.12

  16. 刘勇，杨海堂，卫伟。基于荧光染料TOTO-1分析检测PARP-1活性的方法。CN108300759A，2018．01．31授权。2021，03，10

  17. 卫伟，吴霜霜，刘松琴。一种电化学传感器检测黄曲霉毒素B１的方法。201811416718.3. 授权。2020.12.11

  18. 卫伟，杨海堂，刘松琴。基于核酸染料TOTO-1对单链G序列荧光增强的检测端粒酶活性的方法。201810227750.0，2018.03.20授权2021.07.14

  19. 卫伟，徐晓林，范佳惠，陈昌慧，刘松琴。基于Hemin-石墨烯复合材料的端粒酶活性检测方法。授理号：201610824782.x.

  20. 卫伟,王春蕾,刘松琴.基于DNA行走机器人构建的电化学发光适体传感器检测赭曲霉毒素A的方法。2019100258980.  2019.1.11 2021-06-01

  21. 卫伟，姚田田，卫敏，刘松琴。基于二氧化锰纳米片响应的比率型荧光传感器检测有机磷农药的方法.申请授理号：2019062001289130。 授权日：2021.08.24

  22. 卫伟，陆叶，卫敏，刘松琴。基于辉光型化学发光水凝胶检测有机磷农药的传感器构建.申请授理号：201910727737.6。授权日：20210907

  23. 卫伟，王晨晨。基于免标记的荧光探针构建的FEN1酶活性的检测及细胞成像的方法。授理号：CN201911333073.1授权日：20220308

  24. 卫伟，张多多，刘松琴。基于暗场散射成像的PARP-1单粒子检测方法。申请授理号：CN201911325620.1，授权日2022.4.26

  25. 卫伟，刘梦珂，刘松琴。一种基于金纳米粒子放大QCM信号检测5-羟甲基糠醛的方法。授权

  26. 卫伟，唐艳华，刘松琴。 基于气味结合蛋白的电化学传感器及其构建方法和应用。授权202111008302.X

  27. 卫伟，邵彤，刘松琴。基于主客体相互作用化学发光法检测香兰素分子的分析方法及应用。202111487987.0，授权

  28. 陈钰慧。一种基于表面增强拉曼散射技术定性和定量检测烟碱浓度的方法及应用。授权

近5年代表性论文：

2025

  1. Diantao Chen, Xiaolei Song, Chenchen Wang, Shu Tian, Wei Wei*, Dual-mode optical probe of Eu (III) functionalized luminol-HOF for sensing polyphenols using fluorescence/chemiluminescence. Chem. Eng. J., 520 (2025) 166110.（IF 13.2）

  2. Xiaolei Song, Chenchen Wang, Qin Ding, Peng Li, Shihao Sun, Wei Wei*，Juan Zhang, Rongli Sun, Lihong Yin, Songqin Liu , Yuepu Pu*,Modulation of β secretase and neuroinflammation by biomimetic nanodelivery system for Alzheimer's disease therapy.J. Control. Release.，2025, 378, 735-749. （IF 10.5）

  3. Chenchen Wang, Xiaolei Song, Xiaowan Zhang, Peng Li, Wei Wei*, Shihao Sun**, Yong Chen. Multifunctional natural chlorogenic acid-based nanocarrier for Alzheimer’s disease treatment. Materials Today Bio, 32 (2025) 101841（IF 10.2）

  4. Niya Yang, Xiaowan Zhang, Anran Liu, Yong Wang, Wei Wei*.A sensitive SERS sensor for simultaneous detection of two biomarkers of Alzheimer's disease: AChE and MAO-B. Anal. Chem., 2025, 97, 10893−10900.

  5. Xiaowan Zhang, Xiaolei Song, Chenchen Wang, Duoduo Zhang, Yong Wang, Songqin Liu, Wei Wei*. A dual-mode method for sensitive detection of β-secretase (BACE1) based on surface-enhanced Raman scattering and dark-field microscopy. Anal. Chem., 2025, 97 (33), 18101-18109.

  6. Chenchen Wang, Xiaowan Zhang, Yurong Zhuang, Xiaolei Song, Shihao Sun, Yong Chen, Guihong Qi, Yinan Yang, Peng Li*, Wei Wei*. Natural Bioactive Compounds Solanesol and Chlorogenic Acid Assembled Nanomicelles for Alzheimer’s Disease Therapy. ACS Appl. Mater. Interfaces，2025, 17, 14591−14603.

  7. Yunfei Tang, Mengmeng Xiao, Tongtong Duo, Xiaowan Zhang, Ziyue Chen, Wei Wei*. Simultaneous Detection of MAO-B and Soluble Aβ Oligomers Based on Bimetallic Loaded ZIF-8 Core-shell Probe, ACS Appl. Mater. Interfaces，2025, 17, 36478−36486.

  8. Chenchen Wang, Xiaolei Song, Diantao Chen, Junyu Su, Yong Wang, Wei Wei*. Gold-nanocube-based SERS Sensor for Simultaneous Detection Two Biomarkers of Alzheimer’s Disease, Sensors & Actuators: B. Chemical, 439 (2025)

  9. Diantao Chen, Dingzhong Wang, Xiaolei Song, Chenchen Wang, Peng Li, Shihao Sun, Wei Wei*, Identifying Multiple Polyphenols Using Colorimetric and SERS Dual-Mode Sensor Based on Anti-etching Au@M@Ag Nanorods. Sensors & Actuators: B. Chemical, 2025, 437, 137763 -137770.

  10. Jing Long, Chenchen Wang, Duoduo Zhang, Peng Li, Shihao Sun, Dingzhong Wang, Wei Wei*.Detection of aldehyde compounds in daily and industrial supplies by colourimetry and dark-field microscope imaging. Sensors & Actuators: B. Chemical, 439 (2025) 137838-137845.

  11. Zhenxing Jiang, Chenchen Wang, Xiaolei Song, Yong Wang, Wei Wei*, Dual-mode biosensor for monoamine oxidase B activity detection based on electrochemistry and surface-enhanced Raman scattering. Anal. Chim. Acta, 2025,1368, 344343

  12. Tongtong Duo, Chenchen Wang, Diantao Chen, Shan Liu, Xiujuan Xu,*, Chunqiang Yang, Yong Wang, Wei Wei,*. Determination of Polyphenols in Fruits Based on Metal-Polyphenol Coordination and Surface-Enhanced Raman Scattering Technology. Anal. Chim. Acta, 2025,

  13. Xiaowan Zhang, Chenchen Wang, Yurong Zhuang, Dingzhong Wang, Peng Li*, Shihao Sun and Wei Wei*, Fluorescence detection of 4-hydroxy-2,5-dimethyl-3(2H)-furanone based on fluorescence resonance energy transfer and competitive host-guest recogni-tion. Chemosensors 2025, 13, 110-120

  14. Mengmeng Xiao, Yunfei Tang, Anran Liu, Xiaowan Zhang, Chenchen Wang, Wei Wei*.Fluorescent method for acetylcholinesterase activity detection and its inhibitors screening, Microchemical Journal, 2025, 214, 114147

2024

  1. Yunfei Tang, Xiaolei Song, Mengmeng Xiao, Chenchen Wang, Xiaowan Zhang, Peng Li, Shihao Sun, Dingzhong Wang, Wei Wei, Songqin Liu. Inhibition of Aggregation and Tau Phosphorylation with Functionalized Biomimetic Nanoparticles for Synergic Alzheimer's Disease Therapy. ACS Appl. Mater. Interfaces, 2024, 16, 61774−61786.

  2. Diantao Chen a,1, Dingzhong Wangb,1, Chenchen Wanga, Peng Lib, Shihao Sunb, Yong Wangc, Anran Liua, Wei Weia,*. Self-assembled Au/Ag@MIL(Fe) hybrids for ultra-sensitive SERS detection of furfuryl mercaptan. Sensors & Actuators: B. Chemical 420 (2024) 136507-136514.

  3. Chenchen Wang, Xiaolei Song, Peng Li, Shihao Sun, Juan Su, Songqin Liu, Wei Wei*.Multifunctional Nanoprobe for Synergistic Treatment of Alzheimer’s Disease by Inhibiting β-Amyloid Aggregation and Scavenging Reactive Oxygen Species. ACS Appl. Mater. Interfaces, 2024, 16, 27127−27138.

  4. Yuhui Chen, Anran Liu, Yong Wang, Peng Li*, Yurong Zhuang, Shihao Sun, Dingzhong Wang, Wei Wei *. A dual-mode strategy for diacetyl detection based on colorimetry and surface-enhanced Raman scattering. Sensors & Actuators: B. Chemical 405 (2024) 135336.

2023

  1. Xiaolei Song, Qin Ding, Wei Wei,* Juan Zhang, Rongli Sun, Lihong Yin, Songqin Liu, Yuepu Pu*. Peptide-functionalized prussian blue nanomaterial for antioxidant stress and NIR photothermal therapy against Alzheimer’s disease. Small，2023, DOI: 10.1002/smll.202206959.

  2. Xiao Cheng, Chen Chen Wang, Anran Liu, Yu Liu, Jingjiao Dong, Zhi Wang, Wei Wei,* Songqin Liu. Simultaneous detection of foodborne pathogenic bacteria in milk by fluorescence immunoassay. Spectrochimica Acta, 2023, 285, 121830.

  3. Chenchen Wang, Mengke Liu, Duoduo Zhang, Peng Lia,*, Shihao Suna, Wei Wei*. Detection of β-amyloid peptide aggregates by Quartz Crystal Microbalance based on dual-aptamer assisted signal amplification. Analytica Chimica Acta, 2023, 1244, 340857- 340863.

  4. Chenchen Wang, Anran Liu, Jin Chen, Songqin Liu, Wei Wei*. Sensitive detection of PARP-1 activity by electrochemical impedance spectroscopy based on biomineralization. Analytica Chimica Acta, 2023,1249, 340937-340942.

  5. Tong Shao, Xiaolei Song, Chenchen Wang, Peng Li, Shihao Sun, Dingzhong Wang, and Wei Wei *. Vanillin-Catalyzed and β-CD-Stabilized Highly Sensitive Luminol Chemiluminescence and its Application. Spectrochimica Acta A, 2023, 294, 122535.

  6. Yong Wang, Xiao Cheng, Chenchen Wang, Duoduo Zhang, Anran Liu, Zhi Wang, Wei Wei,* Songqin Liu*. Ag+-gated peroxidase activity of gold nanoparticles for sensitive detection of escherichia coli.  Talanta, https://doi.org/10.1016/j.talanta.2023.124779。

  7. Yurong Zhuang, Chenchen Wang, Yuhui Chen, Peng Li, Dingzhong Wang, Shihao Sun, Wei Wei*. Colorimetry and surface-enhanced raman scattering method for vanillin detection based on two types of reduced silver nanoparticles. SNB，2023， doi:10.1016/j.snb.2023.134267.

  8. Peng Li, Yanhua Tang, Xiaolei Song, Wei Wei.* Olfactory Sensor for Odorants Analysis by Porous Anodic Alumina Nanochannels Coupled with Human Odorant Binding Proteins. Analytical letters, http://dx.doi.org/10.1080/00032719.2023.2227746

  9. Xiaoya Wang, Chenchen Wang, Peng Li, Dingzhong Wang, Shihao Sun, and Wei Wei*. Highly sensitive and label-free electrochemical sensor for menthol detection using differential pulse voltammetry. Journal of Electroanalytical Chemistry, 2023, 941, 117540.

  10. Tong Shao,  Xiaolei Song,  Peng Li, Dingzhong Wang, Shihao Sun,  Wei Wei *, Ru(II)-Modified Metal Organic Framework as Excellent Electrochemiluminescence Emitter for Ultrasensitive Nicotine Detection. Talanta, 2023, 124539.

2022

  1. Nan Jiang, Peng Li*, Shihao Sun, Wei Wei*.A ratiometric fluorescence sensor for 5-hydroxymethylfurfural detection based on strand displacement reaction. Talanta, 238 (2022) 123029-123035.

  2. Mengke Liu, Peng Li*, Haitang Yang, Nan Jiang, Dingzhong Wang, Shihao Sun，Wei Wei*. Detection of 5-hydroxymethylfurfural Based on split-DNAzyme Assisted Signal Amplification via Quartz Crystal Microbalance, Sensors & Actuators: B. Chemical 352 (2022) 131031

  3. Yanhua Tang, Duoduo Zhang, Ye Lu, Songqin Liu, Juan Zhang, Yuepu Pu, Wei Wei*. Fluorescence Imaging of FEN1 Activity in Living Cells Based on Controlled-Release of Fluorescence Probe from Mesoporous Silica Nanoparticles. Biosensors and Bioelectronics, 2022, 214, 114529-114536.

  4. Xiaoya Wang, Xiaolei Song, Peng Li*, Shihao Sun, Jian Mao, Songqin Liu, Wei Wei,*Fluorescence method for monoamine oxidase B detection based on the cage function of glyoxal and phenethylamine on G-rich DNA. Sensors and Actuators B: Chemical,2022, 372, 132624-132630.

  5. Duoduo Zhang , Nan Jiang, Peng Li, Yusheng Zhang, Shihao Sun, Songqin Liu, Wei Wei,* Sensitive Detection of Monoamine oxidase B Based on Localized Surface Plasmon Resonance Induced by Silver Deposited Gold Nanostar. Chem. Commun. 2022, 58, 12329 - 12332.DOI: 10.1039/d2cc05139g

2021

  1. Duoduo Zhang, Wei Wei*,Yong Liu, Yuepu Pu, Songqin Liu.Dual Imaging of Poly(ADP-ribose) Polymerase-1 and Endogenous H2O2 for the Diagnosis of Cancer Cells Using Silver-Coated Gold Nanorods. Anal. Chem. 2021, 93, 48, 16248–16256.

  2. Xiaolei Song, Qin Ding, Juan Zhang, Rongli Sun, Lihong Yin, Wei Wei*,Yuepu Pu*, and Songqin Liu. A Smart Catalyzed Hairpin Assembly-Induced DNAzyme Nanosystem for Intracellular UDG Imaging. Anal. Chem. 2021, 93, 13687−13693.

  3. Duoduo Zhang, Kan Wang, Wei Wei,* Yong Liu, Songqin Liu.Multifunctional Plasmonic Core-Satellites Nanoprobe for Cancer Diagnosis and Therapy Based on Cascade Reaction Induced by MicroRNA. Anal. Chem. 2021, 93, 27, 9521-9530.

  4. Haitang Yang, Chenchen Wang, Ensheng Xu, Yong Liu, Wei Wei *, Songqin Liu. Dual Mode FEN1 Activity Detection Based on Nt.BstNBI Induced Tandem Signal Amplification.Anal. Chem.,2021,93, 16, 6567-6572.

  5. Yunfei Tang, Wei Wei,* Yong Liu, Songqin Liu. Fluorescent assay of FEN1 activity with nicking enzyme assisted signal amplification based on ZIF 8 for imaging in living cells. Anal. Chem.,2021, 93, 11, 4960–4966.

  6. Xiaolei Song, Qin Ding, Yuepu Pu, Juan Zhang, Rongli Sun, Lihong Yin, Wei Wei *. Application of the Dimeric G-Quadruplex and toehold-mediated strand displacement reaction for fluorescence biosensing of ochratoxin A. Biosensors and Bioelectronics, 2021, 192, 113537.

  7. Ensheng Xu, Haitang Yang, Peng Li, Zhuang Wang, Yong Liu, Wei Wei*, Songqin Liu. Dual-mode detection of PARP-1 by fluorescence and chemiluminescence.Sensors and Actuators B: Chemical,2021,330, 129288-129295.

  8. EnshengXu,YahuiFeng,HaitangYang,LuKong,WeiWei,SongqinLiu. Ultrasensitive and specific multi-miRNA detection based on dual signal amplification. Sensors and Actuators B: Chemical.Sensors and Actuators B: Chemical,2021,337, 129745-129751.

卫伟，女，太阳成城集团tyc234cc古天乐教授，博士生导师。1975年2月生，1998年和2001年，分别于河南师范大学获得本科和硕士学位，2004年获得南京大学博士学位。同年到太阳成城集团tyc234cc古天乐工作，先后任职于公共卫生公司和太阳成城集团tyc234cc古天乐。主要涉及的研究领域如下：1.与疾病相关的生物医学检测（蛋白质、酶、DNA等相关标志物检测）；2.肿瘤和神经退行性疾病的诊断和治疗研究；3.环境、食品中农药残留、重金属等有害物质的灵敏检测方法研究；4.食品、烟草、化妆品中香精香料的检测分析；5.食品、烟草中的风味物质（咸、甜、苦、涩、酸）检测传感研究；6.新型纳米材料的合成及其在分析化学（光谱及电化学）研究中的应用。发表SCI论文90余篇，获授权专利20余项。主持并完成国家自然科学基金4项，江苏省自然基金面上项目1项，国家重点研发项目子课题1项。


员工培养：

2023年，陈钰慧获得国家奖学金。

2022年，唐艳华获得国家奖学金。

2019年，王晨晨获得国家奖学金。

2018年，刘叙获得太阳成城集团tyc234cc古天乐优秀硕士论文。

2018年，吴霜霜获得国家奖学金。

2017年，徐晓林获得国家奖学金。

2016年，刘元建、刘叙、吕冰婧获得国家奖学金。

2014年，高春燕获得国家奖学金。


获奖：

2016年，教育部自然科学奖，一等奖， 纳米材料毒理学评价及环境医学应用的基础研究。

2019年，江苏省预防医学科技奖，二等奖，苯造血毒性的机制与生物标志物研究。

科研项目：

  1. 同时检测阿尔茨海默症关键酶活性的方法研究，22274020，国家自然科学基金面上项目。

  2. 聚ADP核糖聚合酶的高通量检测及其生物医学应用研究, 21775019,国家自然科学基金面上项目。

  3. DNA功能化组装及其在肺癌检测和治疗中的应用研究，21475020,国家自然科学基金。

  4. 基于纳米探针的DNA损伤检测新方法及其在化学品基因毒性评价中的应用, 21205014国家自然科学基金青年基金。

  5. 食品安全化学性污染物智能化现场快速检测技术及相关产品研发,科技部重点研发项目，2018YFC1602800，2018年07月- 2021年12月。

  6. 香气释放原位检测。烟草行业烟草香料基础研究重点实验室创新平台开放合作项目。70万，2022.3-2024.12.

  7. 烟碱的电化学检测。15万，2022-2023。郑州烟草研究院。

  8. 涩感物质传感平台构建，20

  9. 。北京生命科技研究院，2024-2025

  10. 绿原酸多功能纳米载体MC-H/R/si制备、表征、功效技术服务，20万，2025-2026

  11. 甜度检测生物传感器及甜度生物学指标量化表征方法研究，46万。2023-2025

  12. 粮食中有机磷和氨基甲酸酯类农药残留荧光快速检测技术开发。20万，2021-2022.

  13. 单胺氧化酶活性的检测。10万，2021.7-2.22.7。

  14. 基于DNA损伤检测的化学品基因毒性评价与筛查新方法, BK2012734，江苏省自然科学基金。

专利：

  1. 卫伟，高春燕，刘松琴。 限制性内切酶和核酸外切酶III的无标记荧光检测DNA和DNA甲基化转移酶活性的检测方法。ZL 201410220070.8.授权公告日，2015年11月24日

  2. 卫伟，康学军，邓慧华，陆祖宏。蜂王浆中乙酰胆碱的检测方法。ZL 200910028454.9授权公告日，2012年04月25日

  3. 卫伟，熊艳翔，刘松琴。基于氧化石墨烯和限制性内切酶的DNA甲基化检测方法及其试剂盒。ZL 201310472714.8 授权公告日，2015年1月28日

  4. 卫伟，倪蔷薇，刘松琴。一种电化学DNA生物传感器及其制备方法与应用。ZL 201410035109.9  授权公告日，2016年2月10日

  5. 卫敏，刘叙，卫伟。基于孔道内和电化学传感定量检测端粒酶活性的方法。ZL 20160319908.8授权公告日，2018.06.12

  6. 卫伟，刘元建，刘松琴。一种金纳米粒子探针比色法检测甲型流感病毒H3N2的方法。ZL 201510152842.3。授权公告日，2016年10月19日

  7. 卫伟，范佳慧，张雪红，徐晓林，陈昌慧，刘松琴。基于苯胺沉积的电化学传感定量检测8-OHdG的方法。授理号：201610824784.9.授权日: 2018.10.16

  8. 卫敏，刘叙，卫伟。基于纳米传感和电化学传感定量检测端粒酶活性的方法。授权：201610319908.8.  

  9. 卫伟，刘叙，刘松琴。利用亚甲基蓝与G-四链体的结合检测端粒酶活性检测方法。授权号：201610824783.4.

  10. 卫伟，陈昌慧，刘松琴。基于阳离子水溶性聚合物的荧光可视化定量检测端粒酶活性的检测方法。授权：201610824309.1.

  11. 卫伟，刘元建，刘松琴。一种通过荧光法同时检测多种miRNA的方法。授权ZL201710011874.0

  12. 卫伟，吴霜霜，刘松琴。一种基于金纳米棒比色法检测多聚腺苷二磷酸核糖聚合酶-1的新方法。授理号：201710669001.9，授权20200602

  13. 刘勇，范佳慧，卫伟。基于聚苯胺沉积的定量检测多聚腺苷二磷酸核糖聚合酶-1活性的方法，201710729580.1

  14. 刘勇，徐晓林，卫伟。基于hemin 石墨烯复合材料分析检测PARP活性的方法，授权, 2020.04.03. Zl 201710638454.5

  15. 刘勇，许超，卫伟。一种PARP-1浓度的检测方法及其应用。ZL202010431252.5.授权日：2021.02.12

  16. 刘勇，杨海堂，卫伟。基于荧光染料TOTO-1分析检测PARP-1活性的方法。CN108300759A，2018．01．31授权。2021，03，10

  17. 卫伟，吴霜霜，刘松琴。一种电化学传感器检测黄曲霉毒素B１的方法。201811416718.3. 授权。2020.12.11

  18. 卫伟，杨海堂，刘松琴。基于核酸染料TOTO-1对单链G序列荧光增强的检测端粒酶活性的方法。201810227750.0，2018.03.20授权2021.07.14

  19. 卫伟，徐晓林，范佳惠，陈昌慧，刘松琴。基于Hemin-石墨烯复合材料的端粒酶活性检测方法。授理号：201610824782.x.

  20. 卫伟,王春蕾,刘松琴.基于DNA行走机器人构建的电化学发光适体传感器检测赭曲霉毒素A的方法。2019100258980.  2019.1.11 2021-06-01

  21. 卫伟，姚田田，卫敏，刘松琴。基于二氧化锰纳米片响应的比率型荧光传感器检测有机磷农药的方法.申请授理号：2019062001289130。 授权日：2021.08.24

  22. 卫伟，陆叶，卫敏，刘松琴。基于辉光型化学发光水凝胶检测有机磷农药的传感器构建.申请授理号：201910727737.6。授权日：20210907

  23. 卫伟，王晨晨。基于免标记的荧光探针构建的FEN1酶活性的检测及细胞成像的方法。授理号：CN201911333073.1授权日：20220308

  24. 卫伟，张多多，刘松琴。基于暗场散射成像的PARP-1单粒子检测方法。申请授理号：CN201911325620.1，授权日2022.4.26

  25. 卫伟，刘梦珂，刘松琴。一种基于金纳米粒子放大QCM信号检测5-羟甲基糠醛的方法。授权

  26. 卫伟，唐艳华，刘松琴。 基于气味结合蛋白的电化学传感器及其构建方法和应用。授权202111008302.X

  27. 卫伟，邵彤，刘松琴。基于主客体相互作用化学发光法检测香兰素分子的分析方法及应用。202111487987.0，授权

  28. 陈钰慧。一种基于表面增强拉曼散射技术定性和定量检测烟碱浓度的方法及应用。授权

近5年代表性论文：

2025

  1. Xiaolei Song, Chenchen Wang, Qin Ding, Peng Li, Shihao Sun, Wei Wei*，Juan Zhang, Rongli Sun, Lihong Yin, Songqin Liu , Yuepu Pu*,Modulation of β secretase and neuroinflammation by biomimetic nanodelivery system for Alzheimer's disease therapy. Journal of Controlled Release. 2025, 378, 735-749.中科院1区Top，10.6

  2. Niya Yang, Xiaowan Zhang, Anran Liu, Yong Wang, Wei Wei*.A sensitive SERS sensor for simultaneous detection of two biomarkers of Alzheimer's disease: AChE and MAO-B. Anal. Chem., 2025, 97, 10893−10900.

  3. Chenchen Wang, Xiaowan Zhang, Yurong Zhuang, Xiaolei Song, Shihao Sun, Yong Chen, Guihong Qi, Yinan Yang, Peng Li*, Wei Wei*. Natural Bioactive Compounds Solanesol and Chlorogenic Acid Assembled Nanomicelles for Alzheimer’s Disease Therapy. ACS Appl. Mater. Interfaces，2025, 17, 14591−14603.

  4. Chenchen Wang, Xiaolei Song, Xiaowan Zhang, Peng Li, Wei Wei*, Shihao Sun**, Yong Chen. Multifunctional natural chlorogenic acid-based nanocarrier for Alzheimer’s disease treatment. Materials Today Bio,32 (2025) 101841

  5. Diantao Chen, Dingzhong Wang, Xiaolei Song, Chenchen Wang, Peng Li, Shihao Sun, Wei Wei*, Identifying Multiple Polyphenols Using Colorimetric and SERS Dual-Mode Sensor Based on Anti-etching Au@M@Ag Nanorods. Sensors & Actuators: B. Chemical, 2025, 437, 137763 -137770.

  6. Jing Long, Chenchen Wang, Duoduo Zhang, Peng Li, Shihao Sun, Dingzhong Wang, Wei Wei*.Detection of aldehyde compounds in daily and industrial supplies by colourimetry and dark-field microscope imaging. Sensors & Actuators: B. Chemical,439 (2025) 137838-137845.

  7. Xiaowan Zhang, Chenchen Wang, Yurong Zhuang, Dingzhong Wang, Peng Li*, Shihao Sun and Wei Wei*, Fluorescence detection of 4-hydroxy-2,5-dimethyl-3(2H)-furanone based on fluorescence resonance energy transfer and competitive host-guest recogni-tion. Chemosensors 2025, 13, 110-120

  8. Mengmeng Xiao, Yunfei Tang, Anran Liu, Xiaowan Zhang, Chenchen Wang, Wei Wei*.Fluorescent method for acetylcholinesterase activity detection and its inhibitors screening, Microchemical Journal, 2025, 214, 114147

  9. Zhenxing Jiang, Chenchen Wang, Xiaolei Song, Yong Wang, Wei Wei*, Dual-mode biosensor for monoamine oxidase B activity detection based on electrochemistry and surface-enhanced Raman scattering. Anal. Chim. Acta, 2025,1368, 344343

  10. Yunfei Tang, Mengmeng Xiao, Tongtong Duo, Xiaowan Zhang, Ziyue Chen, Wei Wei*. Simultaneous Detection of MAO-B and Soluble Aβ Oligomers Based on Bimetallic Loaded ZIF-8 Core-shell Probe,ACS Appl. Mater. Interfaces，2025, 17, 36478−36486.

  11. Diantao Chen#, Xiaolei Song#, Chenchen Wang, Shu Tian, Wei Wei*, Dual-mode optical probe of Eu (III) functionalized luminol-HOF for sensing polyphenols using fluorescence/chemiluminescence. Chemical Engineering Journal，520 (2025) 166110.

  12. Xiaowan Zhang, Xiaolei Song, Chenchen Wang, Duoduo Zhang, Yong Wang, Songqin Liu, Wei Wei*. A dual-mode method for sensitive detection of β-secretase (BACE1) based on surface-enhanced Raman scattering and dark-field microscopy. Anal. Chem.Analytical Chemistry 2025, 97 (33), 18101-18109.

  13. Chenchen Wang, Xiaolei Song, Diantao Chen, Junyu Su, Yong Wang, Wei Wei*. Gold-nanocube-based SERS Sensor for Simultaneous Detection Two Biomarkers of Alzheimer’s Disease, Sensors & Actuators: B. Chemical,439 (2025)

2024

  1. Yunfei Tang, Xiaolei Song, Mengmeng Xiao, Chenchen Wang, Xiaowan Zhang, Peng Li, Shihao Sun, Dingzhong Wang, Wei Wei, Songqin Liu. Inhibition of Aggregation and Tau Phosphorylation with Functionalized Biomimetic Nanoparticles for Synergic Alzheimer's Disease Therapy. ACS Appl. Mater. Interfaces, 2024, 16, 61774−61786.

  2. Diantao Chen a,1, Dingzhong Wangb,1, Chenchen Wanga, Peng Lib, Shihao Sunb, Yong Wangc, Anran Liua, Wei Weia,*. Self-assembled Au/Ag@MIL(Fe) hybrids for ultra-sensitive SERS detection of furfuryl mercaptan. Sensors & Actuators: B. Chemical 420 (2024) 136507-136514.

  3. Chenchen Wang, Xiaolei Song, Peng Li, Shihao Sun, Juan Su, Songqin Liu, Wei Wei*.Multifunctional Nanoprobe for Synergistic Treatment of Alzheimer’s Disease by Inhibiting β-Amyloid Aggregation and Scavenging Reactive Oxygen Species. ACS Appl. Mater. Interfaces, 2024, 16, 27127−27138.

  4. Yuhui Chen, Anran Liu, Yong Wang, Peng Li*, Yurong Zhuang, Shihao Sun, Dingzhong Wang, Wei Wei *. A dual-mode strategy for diacetyl detection based on colorimetry and surface-enhanced Raman scattering. Sensors & Actuators: B. Chemical 405 (2024) 135336.

2023

  1. Xiaolei Song, Qin Ding, Wei Wei,* Juan Zhang, Rongli Sun, Lihong Yin, Songqin Liu, Yuepu Pu*. Peptide-functionalized prussian blue nanomaterial for antioxidant stress and NIR photothermal therapy against Alzheimer’s disease. Small，2023, DOI: 10.1002/smll.202206959.

  2. Xiao Cheng, Chen Chen Wang, Anran Liu, Yu Liu, Jingjiao Dong, Zhi Wang, Wei Wei,* Songqin Liu. Simultaneous detection of foodborne pathogenic bacteria in milk by fluorescence immunoassay. Spectrochimica Acta, 2023, 285, 121830.

  3. Chenchen Wang, Mengke Liu, Duoduo Zhang, Peng Lia,*, Shihao Suna, Wei Wei*. Detection of β-amyloid peptide aggregates by Quartz Crystal Microbalance based on dual-aptamer assisted signal amplification. Analytica Chimica Acta, 2023, 1244, 340857- 340863.

  4. Chenchen Wang, Anran Liu, Jin Chen, Songqin Liu, Wei Wei*. Sensitive detection of PARP-1 activity by electrochemical impedance spectroscopy based on biomineralization. Analytica Chimica Acta, 2023,1249, 340937-340942.

  5. Tong Shao, Xiaolei Song, Chenchen Wang, Peng Li, Shihao Sun, Dingzhong Wang, and Wei Wei *. Vanillin-Catalyzed and β-CD-Stabilized Highly Sensitive Luminol Chemiluminescence and its Application. Spectrochimica Acta A, 2023, 294, 122535.

  6. Yong Wang, Xiao Cheng, Chenchen Wang, Duoduo Zhang, Anran Liu, Zhi Wang, Wei Wei,* Songqin Liu*. Ag+-gated peroxidase activity of gold nanoparticles for sensitive detection of escherichia coli.  Talanta, https://doi.org/10.1016/j.talanta.2023.124779。

  7. Yurong Zhuang, Chenchen Wang, Yuhui Chen, Peng Li, Dingzhong Wang, Shihao Sun, Wei Wei*. Colorimetry and surface-enhanced raman scattering method for vanillin detection based on two types of reduced silver nanoparticles. SNB，2023， doi:10.1016/j.snb.2023.134267.

  8. Peng Li, Yanhua Tang, Xiaolei Song, Wei Wei.* Olfactory Sensor for Odorants Analysis by Porous Anodic Alumina Nanochannels Coupled with Human Odorant Binding Proteins. Analytical letters, http://dx.doi.org/10.1080/00032719.2023.2227746

  9. Xiaoya Wang, Chenchen Wang, Peng Li, Dingzhong Wang, Shihao Sun, and Wei Wei*. Highly sensitive and label-free electrochemical sensor for menthol detection using differential pulse voltammetry. Journal of Electroanalytical Chemistry, 2023, 941, 117540.

  10. Tong Shao,  Xiaolei Song,  Peng Li, Dingzhong Wang, Shihao Sun,  Wei Wei *, Ru(II)-Modified Metal Organic Framework as Excellent Electrochemiluminescence Emitter for Ultrasensitive Nicotine Detection. Talanta, 2023, 124539.

2022

  1. Nan Jiang, Peng Li*, Shihao Sun, Wei Wei*.A ratiometric fluorescence sensor for 5-hydroxymethylfurfural detection based on strand displacement reaction. Talanta, 238 (2022) 123029-123035.

  2. Mengke Liu, Peng Li*, Haitang Yang, Nan Jiang, Dingzhong Wang, Shihao Sun，Wei Wei*. Detection of 5-hydroxymethylfurfural Based on split-DNAzyme Assisted Signal Amplification via Quartz Crystal Microbalance, Sensors & Actuators: B. Chemical 352 (2022) 131031

  3. Yanhua Tang, Duoduo Zhang, Ye Lu, Songqin Liu, Juan Zhang, Yuepu Pu, Wei Wei*. Fluorescence Imaging of FEN1 Activity in Living Cells Based on Controlled-Release of Fluorescence Probe from Mesoporous Silica Nanoparticles. Biosensors and Bioelectronics, 2022, 214, 114529-114536.

  4. Xiaoya Wang, Xiaolei Song, Peng Li*, Shihao Sun, Jian Mao, Songqin Liu, Wei Wei,*Fluorescence method for monoamine oxidase B detection based on the cage function of glyoxal and phenethylamine on G-rich DNA. Sensors and Actuators B: Chemical,2022, 372, 132624-132630.

  5. Duoduo Zhang , Nan Jiang, Peng Li, Yusheng Zhang, Shihao Sun, Songqin Liu, Wei Wei,* Sensitive Detection of Monoamine oxidase B Based on Localized Surface Plasmon Resonance Induced by Silver Deposited Gold Nanostar. Chem. Commun. 2022, 58, 12329 - 12332.DOI: 10.1039/d2cc05139g

2021

  1. Duoduo Zhang, Wei Wei*,Yong Liu, Yuepu Pu, Songqin Liu.Dual Imaging of Poly(ADP-ribose) Polymerase-1 and Endogenous H2O2 for the Diagnosis of Cancer Cells Using Silver-Coated Gold Nanorods. Anal. Chem. 2021, 93, 48, 16248–16256.

  2. Xiaolei Song, Qin Ding, Juan Zhang, Rongli Sun, Lihong Yin, Wei Wei*,Yuepu Pu*, and Songqin Liu. A Smart Catalyzed Hairpin Assembly-Induced DNAzyme Nanosystem for Intracellular UDG Imaging. Anal. Chem. 2021, 93, 13687−13693.

  3. Duoduo Zhang, Kan Wang, Wei Wei,* Yong Liu, Songqin Liu.Multifunctional Plasmonic Core-Satellites Nanoprobe for Cancer Diagnosis and Therapy Based on Cascade Reaction Induced by MicroRNA. Anal. Chem. 2021, 93, 27, 9521-9530.

  4. Haitang Yang, Chenchen Wang, Ensheng Xu, Yong Liu, Wei Wei *, Songqin Liu. Dual Mode FEN1 Activity Detection Based on Nt.BstNBI Induced Tandem Signal Amplification.Anal. Chem.,2021,93, 16, 6567-6572.

  5. Yunfei Tang, Wei Wei,* Yong Liu, Songqin Liu. Fluorescent assay of FEN1 activity with nicking enzyme assisted signal amplification based on ZIF 8 for imaging in living cells. Anal. Chem.,2021, 93, 11, 4960–4966.

  6. Xiaolei Song, Qin Ding, Yuepu Pu, Juan Zhang, Rongli Sun, Lihong Yin, Wei Wei *. Application of the Dimeric G-Quadruplex and toehold-mediated strand displacement reaction for fluorescence biosensing of ochratoxin A. Biosensors and Bioelectronics, 2021, 192, 113537.

  7. Ensheng Xu, Haitang Yang, Peng Li, Zhuang Wang, Yong Liu, Wei Wei*, Songqin Liu. Dual-mode detection of PARP-1 by fluorescence and chemiluminescence.Sensors and Actuators B: Chemical,2021,330, 129288-129295.

  8. EnshengXu,YahuiFeng,HaitangYang,LuKong,WeiWei,SongqinLiu. Ultrasensitive and specific multi-miRNA detection based on dual signal amplification. Sensors and Actuators B: Chemical.Sensors and Actuators B: Chemical,2021,337, 129745-129751.